Drug Interactions Coadministration of probenecid with intravenous acyclovir has been shown to increase the mean acyclovir half-life and the area under the concentration-time curve
Acyclovir distributes into most body tissues, including vesicular fluid and the central nervous system
RBCs store ribavirin for the lifetime of the cells, releasing it into the body's systems when old cells are degraded in the spleen
Mean half-life after oral doses of 300 mg/m 2 and 600 mg/m 2 in pediatric patients aged 7 months to 7 years was 2
Acyclovir Pharmacokinetics in Pediatric Patients (Mean ± SD) Parameter Aged
Adults with normal renal function: initial serum half-life averages
HSV and CMV treatment guidelines are discussed, and multiple treatment
Components of the Half-life Formula
5
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5 to 5 hours in neonates with normal creatinine clearance
Table 2: Acyclovir Half-life and Total Body Clearance For patients who require dialysis, the mean plasma half-life of acyclovir during hemodialysis is approximately 5 hours
If you took 200 mg of acyclovir: 100mg remains after 2
The plasma half-life is 2–3 h in older children and adults with normal renal function and 2
78 to 1
Each gram acyclovir ointment USP, 5% contains 50 mg of acyclovir in a polyethylene glycol (PEG) base
Typical dosage for Mean half-life after oral doses of 300 and 600 mg/m², in children aged 7 months to 7 years, was 2
Mean half-life after oral doses of 300mg/m 2 and 600mg/m 2 in pediatric patients aged 7 months to 7 years was 2
Acyclovir (ACV), or 9-((2-hydroxyethoxy) further evaluated using Sprague–Dawley rats to show an increase in the plasma peak by approximately two-folds and a half-life increase from 4 h (pure drug) to 7 h
Famciclovir is eliminated primarily via the kidneys
74 hours)
Approximately one third of acyclovir in the body is removed by dialysis during a 4-hour hemodialysis session
16 ± 162
This inhibition depends on interactions with thymidine kinase and DNA polymerase
59 to 3
The half-life and total body clearance of acyclovir are dependent on renal function as shown in Table 2