LPS significantly decreased Vps34 expression in N9 microglial cells by activating the PI3KI/AKT/MTOR pathway without affecting the levels of lysosome-associated proteins and enzymes
Microglia are the resident innate immune cells of the central nervous system (CNS)
Activated microglia-mediated neuroinflammation involved in the pathogenesis of subarachnoid hemorrhage-induced brain injury could be alleviated by treatment with bone marrow MSCs
Finally, studies in which microglial PI3K-AKT signaling has been modulated will be highlighted, as this may prove to be a promising therapeutic approach for the future treatment of a range of neuroinflammatory conditions
Dexamethasone (10 μM) was employed as a positive control
Furthermore, microglia numbers remain elevated compared to the uninjured brain at least six weeks after ablation
Microglia are immune cells of the central nervous system that originate from red myeloid progenitor cells in the embryonic yolk sac and subsequently migrate to the brain, where they proliferate and exert their influence [1]
November 2022; dexamethasone (DEX, purity>98%) and SA (Fig
recovery with histomorphometric analysis of nerves and muscles after combination treatment with erythropoietin and dexamethasone in acute peripheral nerve injury
Maturation of postnatal microglia, as we