Patients with advanced non-small cell lung cancer suitable to receive cisplatin-containing regimen were randomly assigned to receive furosemide or mannitol with appropriate hydration
Risk factors for nephrotoxicity Drug- and kidney-specific factors Toxicity of therapeutic and diagnostic agents may be inherent to the pharmacological compound itself and the potential for toxicity may be heightened in the kidney microenvironment
0%) patients given furosemide and in 38 of 222 (17
Monitor renal function
10 furosemide, as in rheumatic disease, may experience salicylate toxicity at lower doses because 11 of competitive renal excretory sites
[1] There are various forms, [2] and some drugs may affect kidney function in more than one way
Nephrotoxicity is the primary dose‐limiting toxicity, and various hydration regimens and supplementation strategies are used to prevent cisplatin‐induced kidney injury
To the best of our knowledge, there have been no studies that have examined Furosemide is a widely used, potent natriuretic drug, which inhibits the Na+-K+-2Cl− cotransporter (NKCC)-2 in the ascending limb of the loop of Henle applied to reduce extracellular fluid volume expansion in heart and kidney disease
Furosemide has a tendency to antagonize the skeletal muscle relaxing effect of tubocurarine and may potentiate the action of succinylcholine
The goal of this multicenter retrospective study was to identify potential risk factors for CDDP nephrotoxicity
Aminoglycosides have long been one of the commonest causes of drug-induced nephrotoxicity ( 137 )
Allergic interstitial nephritis or vasculitis is believed to be the underlying pathologic process
Furosemide is probably not generally useful
It is practically insoluble in water, sparingly soluble in alcohol, freely soluble in dilute alkali solutions and insoluble in dilute acids
The 24-h creatinine clearance was measured before and on day 6 after cisplatin infusion
Male gender, low albumin, and administration of interacting drugs or furosemide during high-dose methotrexate clearance may predispose patients to nephrotoxicity
carboplatin levels, risk of serious infection, myelosuppression, nephrotoxicity, hypokalemia, auditory, vestibular, other adverse effects (additive effects) Aminoglycosides are concentration-dependent, bactericidal agents that undergo active transport into the cell where they inhibit protein synthesis on the 30S subunit of the bacterial ribosome
1979 Apr;39(4):1269-78
The main concerns with the use of aminoglycoside antibiotics are nephrotoxicity and ototoxicity
It is practically insoluble in water, sparingly soluble in alcohol, freely soluble in dilute alkali solutions and insoluble in dilute acids
0 ml 0
A study of high-dose cisplatin (100 mg/m2) together with mannitol or furosemide diuresis in 22 patients showed statistically similar nephrotoxicity: 28% and 19% decreases in cre-atinine clearance (P>0
He had been receiving aspirin and furosemide along with concomitant atorvastatin [atorvastatin calcium] and insulin aspart
In fact, Lehane et al
1 – 3 Among older adults, the incidence of drug-induced
3)
biochemistry is abnormal but safe), high doses of furosemide may achieve a diuresis, preventing the need for fluid removal by dialysis
However, furosemide may cause hearing loss and other adverse events (59, 60)
When evaluating the primary etiologies in renal injury, the incidence of drug
Auditory toxicity
Subjects who received furosemide with matched hydration in prevention of contrast-induced nephropathy (CIN) had a less frequent need for RRT (OR = 0
Undesirable consequences of furosemide, such as worsening of kidney function and unpredictable
Furosemide has a tendency to antagonize the skeletal muscle relaxing effect of tubocurarine and may potentiate the action of succinylcholine
All patients who received at least 72 h of treatment and who had no other cause for nephrotoxicity or auditory toxicity were included in the analysis
Furosemide: One study showed no significant difference in SCR, CRCL, or nephrotoxicity between use of furosemide or mannitol with cisplatin therapy and that both diuretics exhibited similar effects
Furosemide, a potent loop diuretic, is frequently used in different stages of acute kidney injury, but its clinical roles remain uncertain
Furosemide belongs to a group of medicines called loop diuretics (also known as water pills)
The patient fully recovered over the ensuing 4 weeks
The mainstay approach to prevent cisplatin-induced nephrotoxicity is administering intravenous (IV) hydration with isotonic saline to increase renal blood flow, and decline in half-life of cisplatin and urinary cisplatin concentration
LASIX can increase the risk of cephalosporin-induced nephrotoxicity even in the setting of minor or transient renal impairment
Methods: We randomized 49 women who received cisplatin (75 mg/m(2) every 3 weeks) into one of the three hydration arms
Furosemide can acidify the urine, and acidic urine may potentially result in formation of methemoglobin casts in patients with severe intravascular hemolysis [25], which are potentially nephrotoxic and may result in further renal impairment
Ibuprofen, diclofenac, and naproxen have an intermediate nephrotoxicity
47), and the mean age Nephrotoxicity or renal toxicity can be a result of hemodynamic changes, direct injury to cells and tissue, inflammatory tissue injury, and/or obstruction of renal excretion